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The disadvantage of male Ginkgo biloba trees is that they are highly allergenic.

Male Ginkgo biloba trees have an OPALS allergy scale rating of 7 (out of 10), whereas female trees, which can produce no pollen, have an OPALS allergy scale rating of 2.

Japanese cooks add ginkgo seeds (called ginnan) to dishes such as chawanmushi, and cooked seeds are often eaten along with other dishes.

When eaten in large quantities or over a long period, the gametophyte (meat) of the seed can cause poisoning by 4'-O-methylpyridoxine (MPN). Studies have demonstrated the convulsions caused by MPN can be prevented or treated successfully with pyridoxine (vitamin B6).

The first record of Europeans encountering it is in 1690 in Japanese temple gardens, where the tree was seen by the German botanist Engelbert Kaempfer.

Because of its status in Buddhism and Confucianism, the ginkgo is also widely planted in Korea and parts of Japan; in both areas, some naturalization has occurred, with ginkgos seeding into natural forests.

The level of these allergens in standardized pharmaceutical preparations from Ginkgo biloba was restricted to 5 ppm by the Commission E of the former Federal German Health Authority.

Ginkgo has long been cultivated in China; some planted trees at temples are believed to be over 1,500 years old.

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These people should handle the seeds with care when preparing the seeds for consumption, wearing disposable gloves.Ginkgo nuts are used in congee, and are often served at special occasions such as weddings and the Chinese New Year (as part of the vegetarian dish called Buddha's delight).In Chinese culture, they are believed to have health benefits; some also consider them to have aphrodisiac qualities.The symptoms are allergic contact dermatitis safe to handle.Ginkgo may have undesirable effects, especially for individuals with blood circulation disorders and those taking anticoagulants such as aspirin or warfarin, although studies have found ginkgo has little or no effect on the anticoagulant properties or pharmacodynamics of warfarin in healthy subjects.

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